No Priors - AI, Technology, Startups

Elad Gil and Sarah Guo interview AI engineers, researchers and founders. Released as audio and video.

Categories:

development

Links

Subscribe: feeds.megaphone.fm/nopriors Home: linktr.ee/nopriors youtube.com/@NoPriorsPodcast

Episodes

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The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire

9 Apr 2026

Circle aims to build a digital financial infrastructure using programmable money and blockchain, inspired by Bitcoin, emphasizing stablecoins like USDC, Austrian economics principles, full-reserve banking, and the integration of blockchain, AI, and tokenized assets to enable global value transfer, microtransactions, and new economic paradigms while addressing regulatory and scalability challenges.

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AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus

3 Apr 2026

AI's interdisciplinary evolution from physics and dark matter research to material science innovations via Periodic Labs, emphasizing integration with experiments, domain-specific data, and closed-loop systems to advance AI-driven advancements in synthesis, robotics, and industry.

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Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI

20 Mar 2026

The shift from traditional coding to agent-centric workflows redefines development by having AI agents handle 80% of tasks, emphasizing intent-driven "manifestation" over code, while addressing challenges like agent limitations, real-world applications in automation and smart homes, and broader implications for education, ethics, and AI ecosystem dynamics.

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From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last

12 Mar 2026

Notion's adoption of AI agents has increased productivity, but also widened the performance gap between engineers, and is shifting the role of developers from coding to managing agents.

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How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari

26 Feb 2026

An in-depth look at AI infrastructure financing explores Magnetar Capital's investments, AI industry trends, and challenges with traditional funding methods, among other topics.

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From SaaS to AI-First: How Companies Are Reshaping Innovation

19 Feb 2026

Concerns are raised about the quality and sustainability of software development, particularly with the increasing use of AI-generated code and its potential to disrupt traditional engineering practices and industry models.

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Rivians Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe

12 Feb 2026

Autonomous driving technology is evolving towards standardization by 2030, driven by advancements in onboard computing and data analytics, and is shifting towards more complex neural network systems.

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Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki

5 Feb 2026

Artificial intelligence is poised to revolutionize gaming by developing advanced NPCs, immersive simulations, and personalized experiences in a virtual environment akin to a "holodeck".

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Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming

29 Jan 2026

Scientists are exploring reversible cryopreservation to improve organ transplants and ultimately enable medically induced hibernation through whole-body freezing.

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No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai

22 Jan 2026

The podcast delves into the software industry's shift towards integrated platforms that offer long-term value and explores key challenges to becoming a dominant player, including adapting to technological change and scaling revenue.

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